abstract：:Since the first published correlations around the years 1975 between estrogen and progesterone receptors and response to hormone therapy, numerous data have modified our insight on hormone dependency. For instance, it is now well established that tumors are not "receptor positive" or "receptor negative" but contain va...

journal_title：Bulletin du cancer

authors： Goussard J,Génot JY

更新日期：1994-01-01 00:00:00

abstract：:Apparition of new tools in the therapy of multiple (MM) strengthens the need for valuable prognostic categorization of each patient in order to propose the most adequate treatment. Prognostic factors in MM can be divided in four groups. The first, including beta 2 microglobulin (beta 2m), hemopoiesis impairment, osteo...

journal_title：Bulletin du cancer

authors： Bauduer F,Troussard X,Delmer A

更新日期：1993-12-01 00:00:00

abstract：:The p53 gene is known to play a central role in cancer. In fact, no human tumor type is devoid of p53 mutations, although differences can be seen in the relative frequencies and patterns of nucleotide substitutions. Our work illustrates these differences, since frequencies of mutations ranged from 15 to 80% and the pa...

journal_title：Bulletin du cancer

authors： Theillet C

更新日期：1993-08-01 00:00:00

abstract：:Between October 1987 and June 1992, 244 patients with metastatic renal carcinoma were referred to our Institute. One hundred and sixty-nine were included in immunotherapy protocols. The 40 most recent patients were included in the ongoing multicentric randomised Crecy study. The previous patients were treated with IL2...

journal_title：Bulletin du cancer

authors： Négrier S,Mercatello A,Coronel B,Lanier F,Merrouche Y,Bret M,Blay JY,Lasset C,Thiesse P,Carrie C

更新日期：1993-07-01 00:00:00

abstract：:From July 1987 to July 1988, 35 patients with non small cell lung cancer, stage IV, were included in a phase II trial (GLOT NPC 87/01). The treatment was as follows: cisplatin 50 mg/m2 day 1, vindesin 3 mg/m2 day 1, mitomycin 6 mg/m2 day 2, and bleomycin 15 mg/day, day 1 + 2 by continuous infusion. The evaluation for ...

journal_title：Bulletin du cancer

authors： Souquet PJ,Fournel P,Jorda M,Laennec E,Piperno D,Trillet V,Rebattu P,Bernard JP

更新日期：1993-01-01 00:00:00

abstract：:The effects various drugs exert on antioxidant enzyme and glyoxalase activity in rat livers were studied. All drugs tested provoked a marked reduction in glutathione peroxidase and a small drop in both glyoxalase I and II activity. It is hypothesized that the substances tested support tumour development by neutralizin...

journal_title：Bulletin du cancer

authors： Liotti FS,Menghini AR,Guerrieri P,Mariucci G,Armellini R

更新日期：1993-01-01 00:00:00

abstract：:In the last ten years considerable progress has been made in small-cell lung carcinoma (SCLC) biology, along with the technical progress made in molecular biology. This progress now allows us to propose a model for the genesis and the development of this type of tumor. Tobacco, the principal causal factor plays a dual...

journal_title：Bulletin du cancer

authors： Levy R,Andrieu JM,Even P

更新日期：1992-01-01 00:00:00

abstract：:Infectious complications associated with granulocytopenia during the treatment of poor risk or relapsed germ cell tumors were studied in order to assess the frequency, morbidity and characteristics of these complications. Thirty-three cases were investigated at the Institut Gustave-Roussy; 63 episodes of granulocytope...

journal_title：Bulletin du cancer

authors： Ribrag V,Droz JP,Kattan J,Andremont A

更新日期：1992-01-01 00:00:00

abstract：:Twenty-eight patients with poor prognosis, advanced metastatic non seminomatous germ cell tumors (NSGCT) were treated with early high dose chemotherapy and autologous bone marrow transplantation (ABMT) rescue. The primary tumor was testicular in 19 patients and extragonadal in nine patients. For 19 patients with a tes...

journal_title：Bulletin du cancer

authors： Droz JP,Pico JL,Ghosn M,Kramar A,Rey A,Ostronoff M,Baume D

更新日期：1992-01-01 00:00:00

abstract：:Seventy-five patients with locally advanced non small cell lung carcinoma were entered in a phase II study combining chemotherapy (vindesine, lomustine, cisplatin and cyclophosphamide) and radical thoracic radiotherapy delivering a total dose of 60-65 Gy. Patients were regularly assessed by radiological and fiberoptic...

journal_title：Bulletin du cancer

authors： Nasr E,Pellae-Cosset B,Arriagada R,Le Chevalier T,Baldeyrou P,Ruffie P,de Cremoux H,Martin M,Tarayre M

更新日期：1992-01-01 00:00:00

abstract：:Ataxia telangiectasia (AT) is a hereditary disease transmitted in a recessive mode and characterized by chromosomal instability and radiosensitivity. AT patients have a 100-fold higher risk of cancer than the general population. Although AT is a rare disease of which the frequency has been estimated to be 1/40,000, th...

journal_title：Bulletin du cancer

authors： Stoppa-Lyonnet D,Aurias A

更新日期：1992-01-01 00:00:00

abstract：:Thymidine kinase (TK) was assayed in the cytosol of 210 primary breast cancers to assess its predictive value for response to first line chemotherapy and hormonotherapy. We performed correlations between TK and the other prognosis factors of breast cancer. TK activity is correlated with SBR grading and estrogen recept...

journal_title：Bulletin du cancer

authors： Bennini N,Mauriac L,Wafflart J,Bonichon F,Durand M

更新日期：1992-01-01 00:00:00

abstract：:Originally described for its capacity to induce hemorrhagic necrosis of transplantable tumors in mice, TNF-alpha also exerts cytotoxic effects against some tumor cell lines in vitro. It is now known that TNF is an essential mediator of cellular immunity and a wide variety of biological activities of TNF in vitro and i...

journal_title：Bulletin du cancer

authors： Chouaib S,Robinet E,Zyad A,Branellec D

更新日期：1992-01-01 00:00:00

abstract：:The authors report on a case of a woman with acute lymphoblastic leukemia treated with cortisone therapy during pregnancy. No problems were encountered during the gestational period or at parturition; and no maternal or neonatal complications were observed. ...

journal_title：Bulletin du cancer

authors： Hamdoun L,Zeineb NB,Ferchiou M,Zhioua F,Meriah S

更新日期：1992-01-01 00:00:00

abstract：:Forty-six tumors from patients with oropharyngeal carcinoma were analysed by flow cytometry after injection of bromodeoxyuridine (Budr) for the labelling index, the duration of S phase and the potential doubling time (Tpot). The results show large variations in Tpot (from 2.6 to 16.7 days) among these tumors from the ...

journal_title：Bulletin du cancer

authors： Bourhis J,Wilson GD,Janot F,Chavaudra N,Leridant AM,Wibault P,Girinsky T,Luboinski B,Eschwege F,Malaise EP

更新日期：1991-11-01 00:00:00

abstract：:A retrospective, morphological and immunochemical study was performed on 60 bone marrow biopsies (BOM) and 12 tumor specimens surgically excised, from 9 patients with neuroblastoma (NB). Immunochemistry concerned "neuron-specific enolase" (NSE), chromogranin A (CGA) and synaptophysin (SP). The results of immunochemica...

journal_title：Bulletin du cancer

authors： Boman F,Chastagner P,Floquet J,Sommelet D,Aymard B,Palau R,Kleinclaus I

更新日期：1991-01-01 00:00:00

abstract：:The proliferation and the differentiation of B lymphocytes is under the control of T cell and macrophage produced cytokines which drive resting B cells to the state of antibody-producing plasma cells. Antibodies exert a feedback control of their own production via their interaction with Fc receptor (FcR) bearing cells...

journal_title：Bulletin du cancer

authors： Fridman WH

更新日期：1991-01-01 00:00:00

abstract：:Gangliosides are glycosphingolipids which contain neuraminic acid. Although they are present in the plasma membranes of all cells, gangliosides are expressed differently, both quantitatively and qualitatively, in certain types of cancer. Modifications in ganglioside composition may account for some of the abnormal int...

journal_title：Bulletin du cancer

authors： Dumontet C,Portoukalian J

更新日期：1991-01-01 00:00:00

abstract：:The evidence that genetic factors are of some importance in the etiology of cancer originates has been determined by genetic epidemiology, molecular biology, cytogenetics. Genetic counselling is one of the possible strategies for controlling cancer through genetics. Genetic counselling in this field more often concern...

journal_title：Bulletin du cancer

authors： Feingold J

更新日期：1991-01-01 00:00:00

abstract：:Serotonin (5-Hydroxytryptamine) seems to play a dominant role in triggering vomiting induced by cytotoxic agents through the stimulation of 5-HT3 receptors. They have been observed in the GI tract as well as in the brain (area postrema). Ondansetron is a specific antagonist of 5-HT3 serotonin receptors. Its anti-emeti...

journal_title：Bulletin du cancer

authors： d'Allens H,Aubert B,Bons J,Pappo M

更新日期：1991-01-01 00:00:00

abstract：:Screening methods for the detection of anticancer activity are of crucial importance in order to find solid tumor-specific agents. A review of past screening methods is followed by a description of present methodologies targetted toward the discovery of such agents. Finally, we discuss primary and secondary in vivo ev...

journal_title：Bulletin du cancer

authors： Bissery MC,Chabot GG

更新日期：1991-01-01 00:00:00

abstract：:Non transformed epithelial hepatic cells (established cell line and adult rat hepatocytes) treated by liver tumor promoters, phenobarbital and biliverdin, for 24 and 48 h showed a fragmentation and loss of F-actin and a depolymerisation of microtubules. This pattern closely resembles that of transformed cells which we...

journal_title：Bulletin du cancer

authors： Decloître F,Martin M,Ouldelhkim M,Nizard C

更新日期：1990-01-01 00:00:00

abstract：:In terms of pharmacology, drug delivery is an important obstacle in the development of brain tumor chemotherapy. The blood-brain barrier limits the drug penetration in normal brain tissue around the tumor and at distant potential metastatic sites. In the tumor, the altered blood-brain barrier, ie blood-tumor barrier, ...

journal_title：Bulletin du cancer

authors： Vassal G

更新日期：1990-01-01 00:00:00

abstract：:We report a prospective study concerning the association of surgery-chemotherapy and radiotherapy in the treatment of primary high grade digestive non-Hodgkin's lymphomas in 19 patients. The analysis of 11 stages IE, 5 stages II1E and 3 stages II2E allowed us to evaluate the efficacy and the tolerance of this triple t...

journal_title：Bulletin du cancer

authors： Renou P,Colombat P,Fetissof F,Calais G,Metman EH,Combe M,Dugay J,Martin JF,Linassier C,Lamagnere JP

更新日期：1990-01-01 00:00:00

abstract：:CDDP is one of the most active single drugs in non small cell lung carcinoma. High doses of 200 mg/m2 are well tolerated when fractionated doses are used over a period of 5 d. Twenty-four consecutive patients (male, age range 38-70 y) with brain metastasis of lung carcinoma were included in this study. The total dose ...

journal_title：Bulletin du cancer

authors： Kleisbauer JP,Guerin JC,Arnaud A,Poirier R,Vesco D

更新日期：1990-01-01 00:00:00

abstract：:Chemotherapy has dramatically improved the prognosis of non-seminomatous germ cell tumors (NSGCT). However, some patients relapse and others are refractory to first line chemotherapy. We studied a salvage chemotherapeutic regimen with etoposide 75 gm/m2/day, and cisplatin 40 mg/m2/day, days 1-5 and Ifosfamide 3 g/m2/d...

journal_title：Bulletin du cancer

authors： Droz JP,Pico JL,Ghosn M,Ostronoff M,Azab M,Theodore C,Hayat M

更新日期：1990-01-01 00:00:00

abstract：:The biological behaviour of invasive carcinoma of the uterine cervix is not always predictable. It is therefore important to establish new biological markers which could be useful in determining a more reliable prognosis. We have analyzed the c-Ha-ras and c-myc proto-oncogenes in a large series (154 cases) of cervical...

journal_title：Bulletin du cancer

authors： Riou G,Sheng ZM,Zhou D,Lusinchi A,Le Doussal V,Barrois M

更新日期：1990-01-01 00:00:00

abstract：:The study of cases treated between 1970 and 1984 at the Institut Curie, in women aged 40 years and under, was undertaken in order to determine the influence of age on prognosis. The incidence of these cases was stable throughout the 15 years study period as was the very high incidence of earlier cases: 84.5%. Earlier ...

journal_title：Bulletin du cancer

authors： Fenton J,Chevret S,Asselain B,de La Rochefordière A,Mathieu G,Labib A,Durand JC,Salmon RJ

更新日期：1990-01-01 00:00:00

abstract：:Doxifluridine, a new fluorouracil analog with a low myelosuppressive effect, has recently been subject to various disease-oriented, Phase II trials. For the present evaluation of drug tolerance, the Phase II data of 114 patients having received 376 doxifluridine cycles has been used. The treatment cycles consisted of ...

journal_title：Bulletin du cancer

authors： Winkelmann JJ,Alberto P,Mermillod B

更新日期：1990-01-01 00:00:00

abstract：:The authors report a case of endometrial carcinoma treated with tamoxifen introduced after normal initial uterine curettage. Based on recent experimental and clinical data, the importance of a gynecological follow-up in anti-estrogen therapy is emphasized. ...

journal_title：Bulletin du cancer

authors： Rodier JF,Camus E,Janser JC,Renaud R,Rodier D

更新日期：1990-01-01 00:00:00

abstract：:Thirty-two patients with high risk melanoma (either primary melanoma of the limbs or trunk, or recurrent melanoma) and clinically disease-free following appropriate surgical treatment were immunized with a vaccinia virus oncolysate made from a pool of 4 human melanoma cell lines. Injections were given id weekly for 3 ...

journal_title：Bulletin du cancer

authors： Doré JF,Portoukalian J,Berthier-Vergnes O,Jacubovich R,Genève J,Bailly M,Lefthériotis E,Weissbrod A,Mayer M

更新日期：1990-01-01 00:00:00

abstract：:Intraportal continuous infusion of 5-FU (600 mg/m2/24 h during 7 days) was administered in the immediate postoperative course of 6 consecutive patients with colorectal metastases resected for cure (one segmentectomy and 5 nonanatomical local resections). One month later, a systemic continuous infusion of 5-FU was deli...

journal_title：Bulletin du cancer

authors： Seitz JF,Aubert C,Giovannini M,Delpero JR,Houvenaeghel G,Guerinel G,Carcassonne Y

更新日期：1989-01-01 00:00:00

abstract：:The clinico-pathological and epidemiological features of 119 cases of Kaposi's sarcoma diagnosed during the years 1979-1986 in the main pathology department of Rwanda are presented. Skin involvement (89%) was predominant with almost 70% of cutaneous lesions localised on the lower limbs; 11% of cases presented with ext...

journal_title：Bulletin du cancer

authors： Ngendahayo P,Mets T,Bugingo G,Parkin DM

更新日期：1989-01-01 00:00:00

abstract：:The retrospective evaluation of the dose after an irradiation accident is of paramount importance; it allows an adequate selection of patients and the most appropriate treatment can then be proposed. Classical physical dosimetry often lacks precision for dose assessment in such accidents. Cytogenetics, usually more re...

journal_title：Bulletin du cancer

authors： Hennequin C,Cosset JM,Cailleux PE,Girinsky T,Ganem G,Hubert D,Comoy E,Dutreix J

更新日期：1989-01-01 00:00:00

abstract：:In part I of this article, we reviewed the general aspects of childhood brain tumors. In part II, we present the most common neoplasms and their treatment. The quality of the surgical resection appears to be of first importance in the prognosis. Progress in radiotherapy and chemotherapy have contributed to the improve...

journal_title：Bulletin du cancer

authors： Carrie C,Bouffet E,Brunat-Mentigny M,Philip T,Lacroze M

更新日期：1989-01-01 00:00:00

abstract：:Hypoxic cell fraction was measured in a human tumour xenografted on two different animal species: mouse and rat. These results suggest that, while the Na11 tumour response to radiation depends on the host (nude mouse, nude rat), the proportion of hypoxic cells tested with the growth delay assay is independent of the h...

journal_title：Bulletin du cancer

authors： Guichard M,Chavaudra N,Malaise EP

更新日期：1989-01-01 00:00:00

abstract：:Treatment of soft-tissue sarcomas has to deal simultaneously with three goals: 1) to obtain the control of the primary tumor, 2) to preserve the function, and 3) to treat the micrometastatic disease. For local control, surgery remains the most efficient treatment, but the extent of the resection of macroscopically non...

journal_title：Bulletin du cancer

authors： Bui NB

更新日期：1988-01-01 00:00:00

abstract：:Primary chemotherapy is the use of anticancer drugs as the first treatment in patients with localized tumor presentations for which there is an alternative but less than satisfactory treatment. Its most important feature is the preservation of the primary tumor mass as a biologic marker of response, and in this sense ...

journal_title：Bulletin du cancer

authors： Devita VT Jr

更新日期：1988-01-01 00:00:00

abstract：:Twenty-six patients with metastatic breast cancer where treated, after failure of a first line chemotherapy including an anthracycline, with a second line combination of vindesine, methotrexate and thiotepa. Overall tolerance of this treatment was good. There were one complete response and two partial responses. The a...

journal_title：Bulletin du cancer

authors： Comoz M,Chevallier B,Bastit P

更新日期：1988-01-01 00:00:00

abstract：:Northern France is known to have the highest mortality rate for cancers of the upper aerodigestive tract (UADT); a UADT cancer registry was therefore set up in this region in January 1984. Three years of meticulous registration provided some significant information. The incidence of UADT cancer was alarming: 4538 UADT...

journal_title：Bulletin du cancer

authors： Adenis L,Lefebvre JL,Cambier L

更新日期：1988-01-01 00:00:00